An American Bulldog is typically a happy, friendly, and assertive dog that is at ease with its family and fine with outsiders who pose no threat. They bond strongly with their master and family. This breed also loves children and does well with them, provided they are socialized or obedience trained early to expose them to other dogs and people in order to ensure that they can be controlled around company as they mature. This can be done in the simplest of ways by walking them regularly in a local park where they can meet other people and dogs. If properly socialized, this breed can become a great family pet and guard dog.

They are working dogs with high energy drives, and so American Bulldogs do best in a home with a large backyard and plenty of exercise. They can sometimes be wary towards cats and smaller pets, but the correct socialization at an early age (see above, temperament) can greatly increase the chances of them accepting these animals.